SyncoZymes

ibicuruzwa

Cyclooxygenase (COX)

Ibisobanuro bigufi:

Ibyerekeye Cyclooxygenase

ES-COX (Cyclooxygenase): itera ihinduka ryimigozi ya C = C kuri epoxide.Hariho ubwoko 11 bwibicuruzwa bya enzyme ya COX (Umubare nka ES-COX101 ~ ES-COX-111) byakozwe na SyncoZymes.Ukurikije uburyo butandukanye bwa catalitiki, COX ya SyncoZymes igabanijwemo haloperoxidase na styrene monooxygenase.ES-COX101, 102, 107-111 ni iya haloperoxidase, naho ES-COX103-106 ni iya monoxygenase ya styrene.

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E-Mail:lchen@syncozymes.com


Ibicuruzwa birambuye

Ibicuruzwa

Ibyerekeye Cyclooxygenase:

Ubwoko bwa catalitiki yerekana:

Haloperoxidase:

Cyclooxygenase COX2

Styrene monooxygenase:

Cyclooxygenase COX3

Amakuru y'ibicuruzwa:

Cyclooxygenase COX
Enzymes Kode y'ibicuruzwa Ibisobanuro
Ifu ya Enzyme ES-COX-101 ~ ES-COX-110 urutonde rwa 10 NADH Cyclooxygenase, 50 mg buri kintu 10 * 50mg / ikintu, cyangwa ubundi bwinshi

Ibyiza:

Sub Substrate yihariye.
Guhitamo chiral ikomeye.
Guhindura byinshi.
Ibicuruzwa bike.
Conditions Imiterere yoroheje.
Yangiza ibidukikije.

Amabwiriza yo gukoresha:

➢ Mubisanzwe, haloperoxidase reaction reaction ikubiyemo: substrate, buffer, enzyme, H2O2 na halogen ion.Sisitemu ya reaction ya Styrene monooxygenase ikubiyemo substrate, buffer, enzyme, coenzyme na sisitemu yo kuvugurura coenzyme.
➢ COX igomba kongerwaho nyuma muri sisitemu yo kwitwara, nyuma ya pH nubushyuhe byahinduwe kumiterere.

Ingero zo gusaba:

Urugero rwa 1 (Synthesis ya epoxy styrene ikomoka kuri styrene)(1):

Cyclooxygenase COX4

Icyitonderwa: ingero zikoreshwa hamwe nibisobanuro bigamije kwerekana urugero rwa porogaramu ya COX kugirango byoroshye kumvikana, kandi ntabwo bihuye na enzyme yihariye ya SyncoZymes.

Ububiko:

Komeza imyaka 2 munsi -20 ℃.

Icyitonderwa:

Ntuzigere uhura nibihe bikabije nka: ubushyuhe bwo hejuru, hejuru / hasi ya pH hamwe nubushakashatsi bwimbitse.

Reba:

1. Lin, Hui, Yan Liu, na Zhong-Liu Wu.Tetrahedron: Asimmetry 22.2 (2011): 134-137.


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