Amine Dehydrogenase (AmDH)
Ibisobanuro bigufi:
Ibyerekeye Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): enzyme ishobora guhagarika ammoniation yitsinda rya karubone ikayigabanya mumatsinda ya amino.Ni coenzyme NADH iterwa na enzyme, kandi NADH ikora nka hydrogène yohereza.Hariho ubwoko 4 bwibicuruzwa bya enzyme ya AmDH (Umubare nka ES-AmDH101 ～ ES-AmDH104) byakozwe na SyncoZymes, bishobora gukoreshwa muri regioselective cyangwa stereoselective reductive amination ya aldehydes na ketone.
Ubwoko bwa catalitiki yerekana:
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E-Mail:lchen@syncozymes.com
Sub Substrate yihariye.
Guhitamo chiral ikomeye.
Guhindura byinshi.
Ibicuruzwa bike.
Conditions Imiterere yoroheje.
Yangiza ibidukikije.
➢ Mubisanzwe, sisitemu yogukora igomba kuba irimo substrate, igisubizo cya buffer, enzyme, coenzyme na coenzyme sisitemu yo kuvugurura (urugero glucose na glucose dehydrogenase).
➢ AmDH igomba kongerwaho bwa nyuma muri sisitemu yo kwitwara, nyuma ya pH nubushyuhe byahinduwe kumiterere.
Urugero rwa 1 (Synthesis ya chiral amine ijyanye no kugabanya aminike ya alkyl aryl ketone)(1):
Komeza imyaka 2 munsi -20 ℃.
Ntuzigere uhura nibihe bikabije nka: ubushyuhe bwo hejuru, hejuru / hasi ya pH hamwe nubushakashatsi bwimbitse.
1. Kong W, Liu Y, Huang C, n'abandi.Angewandte Chemie Edition International Edition, 2022: e202202264.
