β-Nicotinamide adenine dinucleotide (aside yubusa) (NAD)
NAD ni coenzyme isanzwe ya dehydrogenase mubinyabuzima bizima.Ifite uruhare muri redox reaction mubinyabuzima bizima, kandi itwara kandi ikohereza electron kubintu kubintu.Dehydrogenase igira uruhare rukomeye muri metabolism yabantu.Bimwe mubikorwa byibanze byimikorere yumubiri wumuntu, nko kubora kwa poroteyine, kubora kwa karubone, no kubora ibinure, ntibishobora gukorwa mubisanzwe nta dehydrogenase, kandi abantu bazabura ibimenyetso byingenzi.Kandi kubera ko guhuza NAD na dehydrogenase bishobora guteza metabolisme, NAD rero nikintu cyingenzi mumubiri wumuntu.Ukurikije imikoreshereze yibicuruzwa, irashobora kugabanywa mu byiciro bikurikira: icyiciro cya biotransformation, icyiciro cyo gusuzuma reagent, icyiciro cyibiribwa byubuzima, API no gutegura ibikoresho bibisi.
| Izina ryimiti | Nikotinamide adenine dinucleotide (aside yubusa) |
| Synonyme | β-Nicotinamide adenine dinucleotide |
| Umubare CAS | 53-84-9 |
| Uburemere bwa molekile | 663.43 |
| Inzira ya molekulari | C21H27N7O14P2 |
| EINECS 号: | 200-184-4 |
| Ingingo yo gushonga | 140-142 ° C (decomp) |
| ububiko bwa temp. | -20 ° C. |
| gukemura | H2O: 50 mg / mL |
| ifishi | Ifu |
| ibara | Cyera |
| Merk | 14,6344 |
| BRN | 3584133 |
| Igihagararo: | Ihamye.Hygroscopique.Ntibishobora gukoreshwa na okiside ikomeye. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Ikizamini | Ibisobanuro |
| Kugaragara | Ifu yera-yera-ifu ya kristaline |
| Isesengura rya UV εkuri 260 nm na pH 7.5 | (18 ± 1.0) × 10³ L / mol / cm |
| Gukemura | 25mg / mL 25mg / mL mumazi |
| Ibirimo (ukoresheje isesengura ryimikorere hamwe na ADH kuri pH 10, ukoresheje spekitifotometero, abs.340nm, kuri anhydrous) | ≥98.0% |
| Suzuma (na HPLC, ku buryo budasanzwe) | 98.0 ~ 102.0% |
| Isuku (na HPLC, agace ka%) | ≥99.0% |
| Ibirimo amazi (by KF) | ≤3% |
Ipaki:Icupa, umufuka wa aluminium, 25kg / Ikarito yingoma, cyangwa ukurikije ibyo umukiriya asabwa.
Imiterere y'Ububiko:Komeza uhagarare neza mwijimye, kubikwa igihe kirekire komeza kuri 2 ~ 8 ℃.
Urwego rwa Biotransformation: Irashobora gukoreshwa muri synthesis ya biocatalytic ya farumasi ihuza imiti na APIs, cyane cyane hamwe na enzymes ya catalitike, nka ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), gukora dehydrogenase (FDH)), glucose dehydrogenase (glucose dehydrogenase) GDH), nibindi, bishobora gufatanya guhindura imiyoboro itandukanye ya aside amine nindi miti ifitanye isano.Kugeza ubu, inganda nyinshi zimiti zo murugo zatangiye gukoresha insimburangingo ya biologiya, kandi isoko rya NAD + ryiyongera cyane.
Urwego rwo kwisuzumisha reagent: Uhujwe na enzymes zitandukanye zo gusuzuma, nkibikoresho fatizo byibikoresho byo gusuzuma.
Urwego rwibiryo byubuzima: NAD ni coenzyme ya dehydrogenase.Ifite uruhare rudasubirwaho muri glycolysis, gluconeogenezesi, inzinguzingu ya aside ya tricarboxylic, hamwe nu ruhererekane rw'ubuhumekero, igira uruhare runini mu kubyara ingufu, kandi ifasha mu gukora L-dopa, ihinduka dopamine Neurotransmitters.Cyane cyane mu myaka yashize, byagaragaye ko ari "moteri" na "lisansi" mugikorwa cyo gusana ibyangiritse.Nk’uko ubushakashatsi bubyerekana, inyongera ya coenzymes (harimo NMN, NR, NAD, NADH) muri vitro irashobora kongera ubushobozi bwa antioxydeant ya selile selile, ikabuza ibimenyetso bya apoptose, kugarura imikorere yimikorere isanzwe, gukumira indwara cyangwa kubuza indwara.
Byongeye kandi, coenzymes irashobora kongera ubushobozi bwokwirinda indwara mugukora no guteza imbere gukura kwingirabuzimafatizo z'umubiri, kubyara ibintu birwanya inflammatory no guhagarika ingirabuzimafatizo za T.Nicotinamide dinucleotide oxydeire (NAD +) ni coenzyme iboneka mu ngirabuzimafatizo zose.Ifite uruhare runini mubikorwa amagana ya metabolike mu ngirabuzimafatizo, igira uruhare mu bihumbi n'ibihumbi bya physiologique, kandi ni umwe mu bagize uruhare runini mu gutwara ibintu bya elegitoroniki.Umuterankunga wa hydrogen;icyarimwe, coenzyme I ikora nka substrate yonyine yimisemburo ifitanye isano mumubiri, ifasha gukomeza ibikorwa byimisemburo.
Nikotinamide mononucleotide (NMN) nicyo kibanziriza icya nicotinamide adenine dinucleotide oxydeire (NAD +), igira uruhare muri synthesis ya NAD muri vivo.Mu mwaka wa 2013, Porofeseri David Sinclair wo mu Ishuri Rikuru ry’Ubuvuzi rya Harvard yasanze uko imyaka igenda ishira, urwego rwa cofactor coenzyme I (NAD +) rwa poroteyine ndende mu mubiri rukomeje kugabanuka, bigatuma igabanuka ry’imikorere ya mitochondial ya "dynamo" y'akagari, bigatuma gusaza , hamwe nibintu bitandukanye mumubiri.Imikorere mibi yubwoko bwimikorere rero ikorwa.Nk’uko ubushakashatsi bwe bubyerekana, ibiri muri NAD + mu mubiri w’umuntu bigabanuka uko imyaka igenda ishira, bigatuma gusaza byihuse kuva ku myaka 30, hamwe n’iminkanyari, kuruhura imitsi, kwegeranya amavuta, n'indwara nk'indwara z'umutima, umuvuduko ukabije w'amaraso, inkorora , diyabete n'indwara ya Alzheimer byongera ibyago.Urufunguzo rwo kuramba ni ukongera urwego rwa coenzyme I (NAD +) mu mubiri, kongera umuvuduko wa metabolism selile, no gukangurira imbaraga z'ubusore.
API no gutegura ibikoresho fatizo: NAD + ikoreshwa mu gutera inshinge zo kuvura / kugenzura ibiyobyabwenge, harimo na NAD IV ivura imitsi ikoreshwa muri Amerika, Uburayi, Uburusiya, Afurika y'Epfo, Mexico, Amerika y'Epfo, Aziya y'Amajyepfo y'Uburasirazuba n'ibindi bihugu.Ibicuruzwa bya farumasi byateguwe, bisa na farumasi zo muri Amerika, birashobora kugura ibikoresho fatizo byo gutanga ubwabo, kimwe n’ibitegurwa n’ibitaro by’Ubushinwa, bigenzura ubwiza bw’ibikoresho fatizo byonyine, kandi bigategura imyiteguro y’imiti.
