Abashakashatsi bo muri Ositaraliya ubushakashatsi bwerekana ko NMN ishobora gukomeza amagufwa

Mugihe tugenda dusaza, amagufwa yacu aracika intege kandi akunda kuvunika, kandi ubuvuzi bwa none burashobora gusa kwiyoroshya ubwinshi bwamagufwa.Iki kibazo kivuka igice kinini kuko impamvu nyamukuru itera osteoporose (kugabanuka kwamagufwa nubucucike) ntibizwi.

Vuba aha, abashakashatsi bo muri Ositaraliya basohoye ibyavuye mu bushakashatsi bwa siyansi mu kinyamakuru cya Gerontologiya: Urukurikirane A: NMN irashobora kugabanya gusaza kw ingirangingo z'amagufa y'abantu kandi igatera gukira amagufwa mu mbeba za osteoporotic.Abanditsi bagize bati: "Ibyavuye mu bushakashatsi byerekana NMN nk'umukandida mwiza kandi ushoboka wo kuvura indwara zo kwirinda ostéoporose no kongera amagufwa ku bantu bakuze barwaye osteoporose".

、 、NMNiteza imbere kuvugurura osteoblasts kandi ikongera ubunini bwamagufwa

Kimwe nizindi ngingo zo mumubiri wumuntu, amagufwa agizwe ningirabuzimafatizo.Kubwibyo, amagufwa ashaje kandi yangiritse ahora asimburwa nandi mashya.Ariko, uko tugenda dusaza, osteoblasts nkeya irahari, igice kuko osteoblasts isanzwe iba selile senescent.Ingirabuzimafatizo, zishobora gutwara gusaza, ntizishobora gukora amagufwa mashya, biganisha kuri osteoporose.​

Abashakashatsi bo muri Ositaraliya bakoze ubushakashatsi ku ngaruka za NMN kuri osteoporose biga osteoblasts y'abantu.Kugira ngo umusaza utangire, abashakashatsi berekanye osteoblasts ku kintu gitera inflammatory cyitwa TNF-⍺.Nubwo TNF-⍺ yihutisha gusaza, kuvura hamwe na NMN byagabanije gusaza inshuro zigera kuri 3, kandi ibisubizo byagaragaje ko NMN yagabanije osteoblasts ya senescent.

Osteoblasts nzima ikora amagufwa mashya muguhindura ingirabuzimafatizo zikuze.Abashakashatsi basanze gutera senescence hamwe na TNF-⍺ byagabanije ubwinshi bw'utugingo ngengabuzima dukuze.Nyamara, NMN yongereye ubwinshi bwingirabuzimafatizo zikuze, kandi ibisubizo byerekana ko NMN ishobora guteza imbere amagufwa.

Nyuma yubushakashatsi bwerekanye koNMNbishobora kugabanya osteoblasts ya senescent no guteza imbere itandukaniro ryayo mumagufa akuze, abashakashatsi bapimye niba ibyo bishobora kubaho mubinyabuzima.Kugira ngo babikore, bakuyemo intanga ngore z’imbeba z’abagore kandi bavunagura amaguru yazo, bikaviramo gutakaza amagufwa aranga osteoporose.

Kugirango bagerageze ingaruka za NMN kuri osteoporose, abashakashatsi bateye imbeba osteoporotic hamwe na 400 mg / kg / kumunsi wa NMN amezi 2.Byagaragaye ko imbeba zifite osteoporose zongereye amagufwa, byerekana ko NMN yahinduye igice ibimenyetso bya osteoporose.Ufatanije namakuru ya osteoblast yumuntu, bivuze ko NMN ishobora kuvura osteoporose mukongera amagufwa.

二 effects Ingaruka zongera amagufwa ya NMN

Ibisubizo byubushakashatsi byerekana koNMNirashobora guteza imbere amagufwa.Bigaragara kubikora muburyo butandukanye, harimo kuvugurura ingirangingo z'amagufwa, zikenerwa mu gukora amagufwa na NAD +, ari ngombwa mu gukora amagufwa.Utugingo ngengabuzima tw'amagufa dutandukanya osteoblasts, kandi abashakashatsi berekanye ko NMN ishobora kandi kuvugurura osteoblasts.​

Ubu bushakashatsi bwerekana ko NMN ishobora kongera amagufwa iteza imbere ubuzima bwingirabuzimafatizo nyinshi mu nzira yo gukora amagufwa.Nubwo nta bisubizo byubushakashatsi byerekana ko NMN ishobora guteza imbere amagufwa kubantu barwaye osteoporose, birashoboka ko NMN ishobora kubuza iterambere ryamagufwa abaho hamwe nimyaka.