Imine reductase (IRED)
Ibisobanuro bigufi:
Kubijyanye na Imine reductase
ES-IRED: Urwego rwa enzymes zituma igabanuka rya C = N ihuza CN.Nibya redox enzyme, hamwe na coenzyme NADPH yo gutwara hydrogen.Ukurikije chiral ikunda ibicuruzwa, birashobora kugabanywa R-IRED na S-IRED.Syncozymes yateje imbere imine 15 (numbIRED ES-IRED-101-ES-IRED-115), ishobora gukoreshwa cyane mukugabanya regioselective na stereoselective kugabanya imine kugirango bategure amine ya chiral.
Ubwoko bwa catalitiki yerekana:
Terefone / Wechat / WhatsApp: + 86-13681683526
E-Mail:lchen@syncozymes.com
| Enzymes | Kode y'ibicuruzwa | Ibisobanuro |
| Ifu ya Enzyme | ES-IRED-101 ~ ES-IRED-114 | urutonde rwa 14 Imine Kugabanya, 50 mg buri umwe |
| 96-Nibyiza Enzyme Yerekana Igikoresho | ES-IRED-1400 | urutonde rwa 14 Imine Kugabanya, mg 1 imwe |
Sub Substrate yihariye.
Guhitamo chiral ikomeye.
Guhindura byinshi.
Ibicuruzwa bike.
Conditions Imiterere yoroheje.
Yangiza ibidukikije.
➢ Mubisanzwe, sisitemu yo kwitwara igomba kuba irimo substrate, igisubizo cya buffer, enzyme, coenzyme, na sisitemu yo kuvugurura coenzyme.
Types Ubwoko bwose bwa ES-IREDs bujyanye nuburyo bwiza bwo kwitwara bugomba kwigwa kugiti cye.
Kwibanda cyane Substrate cyangwa ibicuruzwa hamwe bishobora kubuza ibikorwa bya ES-IRED.Ariko, kubuzwa birashobora koroherezwa mugice cyo kongeramo substrate.
Urugero rwa 1 (Biosynthesis ya chiral 2-methyl pyrrolidine)(1):
Urugero rwa 2 (Biosynthesis ya kabiri amine)(2):
Urugero rwa 3 (Kugabanya Imine Cycle)(3):
Komeza imyaka 2 munsi -20 ℃.
Ntuzigere uhura nibihe bikabije nka: ubushyuhe bwo hejuru, hejuru / hasi ya pH hamwe nubushakashatsi bwimbitse.
1. Scheller PN, Fademrecht S, Hofelzer S, nabandi.ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, n'abandi.ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, n'abandi.Umujyanama.Synth.Catal.2015, 357, 1692-1696.
