Ubushakashatsi Express |Ubushakashatsi bwa kaminuza ya Tsinghua bwerekana ko NMN ishobora kuvura umuriro

Gukora Macrophage ni uburyo butera indwara iganisha ku gutwika indwara zidakira mu mubiri, ariko gukora macrophage bikomeje bishobora gutera indwara zidakira ndetse n'indwara nko kurwanya insuline n'indwara zikomeye nka atherosklerose.PGE 2, ihuza igisubizo cyo gutwika, ikomatanyirizwa muri aside arachidonic na cyclooxygenase (COX-1 na COX-2).COX-1 na COX-2 nibyo byibasiwe cyane no kurwanya inflammatory kandi birashobora guhagarikwa n’imiti itari steroidal anti-inflammatory (NSAIDs).

gukoresha NSAIDs birashobora gutera ingaruka mbi nyinshi, nko kuva amaraso gastrointestinal.Niyo mpamvu, ni ngombwa cyane cyane kubona ibintu bisanzwe byizewe bivura umuriro.

Vuba aha, itsinda ry’ubushakashatsi ryaturutse muri kaminuza ya Tsinghua ryavuye macrophage yimbeba hamwe na NMN, kandi ryerekanye mubushakashatsi ko NMN ishobora kugabanya ikwirakwizwa rya poroteyine ziterwa n’umuriro hamwe n’ibicuruzwa biva mu mahanga, kandi bikabuza gukemura ibibazo bya macrophage.Imipaka muri Molecular Biosciences.

Gutwika bihindura urwego rwa metabolike byproducts muri macrophage
Ubwa mbere, itsinda ry’ubushakashatsi ryakoze macrophage kugirango ritange umuriro binyuze muri lipopolysaccharide (LPS), hanyuma risesengura ibikubiye mu bicuruzwa biva hafi ya macrophage mugihe cyo gutwika.Urwego rwa metabolite 99 rwiyongereye kandi metabolite 105 yagabanutse muri molekile 458 zagaragaye mbere na nyuma yo gukongoka, kandi urwego rwa NAD + ruherekeza umuriro narwo rwaragabanutse.

(FIGURE 1)

NMN yongera urwego rwa NAD kandi igabanya macrophage inflammation
Itsinda ry’ubushakashatsi ryahise rivura macrophage hamwe na LPS, itera indwara, IL-6 na IL-1β, cytokine itera inflammatory ikora nk'ikimenyetso cyo gutwika.Nyuma yo kuvura NMN kuvura macrophage yatewe na LPS, byagaragaye ko urwego rwa NAD rudasanzwe rwiyongereye kandi imvugo ya mRNA ya IL-6 na IL-1β yagabanutse.Ubushakashatsi bwerekanye ko NMN yongereye urwego rwa NAD kandi ikongerera LPS iterwa na macrophage inflammation.

(Isanamu 2)

(Isanamu 3)

NMN igabanya urugero rwa poroteyine zijyanye no gutwika
Ubuvuzi bwa NMN, byagaragaye ko poroteyine zijyanye no gutwika nka RELL1, PTGS2, FGA, FGB na igkv12-44 zagabanutse mu ngirabuzimafatizo, ibyo bikaba byerekanaga ko NMN yagabanije imvugo ya poroteyine ziterwa no gutwika.

(Isanamu 4)

NMN igabanya imvugo ya poroteyine ya NSAIDS
Ubushakashatsi bwa nyuma bwerekanye ko NMN yagabanije urwego rwa PGE2 muri selile RAW264.7 ikora LPS igabanya urwego rwo kwerekana imvugo ya COX-2, bityo igabanya imvugo ya COX2 ikanabuza LPS iterwa no gutwikwa.

(Isanamu 6)

Umwanzuro, inyongera ya NMN irashobora kuvura neza imishwarara idakira yimbeba, kandi kuvura indwara yabantu biracyakeneye kugenzurwa nigeragezwa ryamavuriro.Ahari NMN izahinduka umusimbura wa NSAIDS mugihe cya vuba.

Reba:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide agabanya LPS iterwa na LPS na Oxidative Stress binyuze mu kugabanya imvugo ya COX-2 muri Macrophage.Imbere Mol Biosci.2021 Nyakanga 6.