Intanga ngore ni intangiriro y'ubuzima bw'umuntu, ni intanga ngore itarakura neza amaherezo ikura ikaba igi. Ariko, ubwiza bwa intanga ngore buragabanuka uko abagore bakura cyangwa bitewe n'ibintu nk'umubyibuho ukabije, kandi intanga ngore nke ni zo mpamvu nyamukuru ituma abagore babyibushye baba bake. Ariko, uburyo bwo kunoza ubwiza bwa intanga ngore mu bagore babyibushye ni ikibazo ku bahanga mu bya siyansi.
Vuba aha, ubushakashatsi bwitwa Administration of nicotinamide mononucleotide butuma imbeba zibyibushye zikora neza bwasohotse mu bushakashatsi ku kwiyongera kw'uturemangingo. Ubwo bushakashatsi bwagaragaje ko kongeramo nicotinamide adenine dinucleotide (NAD+) ari byo bitera indwara.nicotinamide mononucleosideAcide (NMN) ishobora kunoza neza ububyimbirwe bw'intanga ngore, kongera ubwiza bw'intanga no gusubiza ibiro by'abana mu mbeba z'ingore zibyibushye cyane.
Abashakashatsi batoranyije imbeba z’ingore zifite ibyumweru 3 n’iz’ingabo zifite ibyumweru 11 kugira ngo bashyireho icyitegererezo cy’umubyibuho ukabije w’imbeba bakoresheje indyo irimo ibinure byinshi kandi byemejwe hakoreshejwe uburyo bwo kwandika ibiro, gupima isukari mu maraso yiyiriza ubusa, no gupima isukari mu kanwa, uburyo bwo kurya 1 Mu byumweru 2,NMNInyongeramusaruro zatewe mu minsi 10 yikurikiranya kugira ngo hamenyekane imiterere y’uturemangingo dufitanye isano n’iterambere ry’intanga n’uturemangingo dufitanye isano n’ububyimbirwe, ingano y’ibinure by’uturemangingo tw’amafuta yo mu nda, urwego rwa ogisijeni rw’ubwoko bwa oocytes, imiterere ya chromosome ya spindle, Imikorere ya mitochondrial, imiterere ya actin, n’ibyangiritse bya ADN, ugereranije n’ibyavuye mu mibare bigaragaza:
1. Uburyo bw'imbeba zirimo ibinure byinshi bwashyizweho neza
Agaciro ka FGB k'itsinda ry'indyo ifite ibinure byinshi (HFD) kari hejuru cyane ugereranyije n'itsinda ry'indyo isanzwe (ND), byongeye kandi, ibisubizo bya OGTT byagaragaje ko imbeba zo mu itsinda ry'indyo ifite ibinure byinshi (HFD) zitashoboraga kwihanganira isukari.
2. NMN ishobora kunoza imikorere mibi y'umubiri mu mbeba za HFD
Inyongera hamwe naNMNInyongeramusaruro zagabanyije ingano y'ibinure mu mbeba zo mu itsinda ry'indyo irimo ibinure byinshi (HFD), kandi ibisubizo bigaragaza ko NMN igira ingaruka ku ihinduka ry'umubiri ridasanzwe mu mbeba zo mu itsinda ry'indyo irimo ibinure byinshi (HFD).
3. NMN yongera ubwiza bw'intanga mu mbeba za HFD
NMN ishobora kongera ubwiza bw'intanga mu mbeba zifite ibinure byinshi (HFD) binyuze mu kugenzura igaragara ry'uturemangingo tw'ingenzi tujyanye n'iterambere ry'uturemangingo tw'intanga (Bmp4, Lhx8) no kubyimba.
4. NMN igabanya ubusembwa bw'igabanywa ry'amagi n'ubwangirike bwa ADN mu mbeba za HFD
NMN ishobora kugabanya inshuro nyinshi z'ubusembwa bw'impinja n'ihindagurika rya chromosome riterwa n'indyo irimo ibinure byinshi (HFD), ikagabanya ibimenyetso bya γH2A.X, kandi ikagabanya kwangirika kwa ADN guterwa n'indyo irimo ibinure byinshi (HFD) binyuze mu kugabanya imikorere ya Bax.
5. NMN ishobora kongera ubwiza bw'uturemangingo tw'amaraso
NMN ishobora gusana igabanuka ry’imisemburo ya SOD1 irwanya antioxydant mu itsinda ry’ibinure byinshi (HFD), kunoza ikwirakwizwa rya mitochondria, no kunoza ubwiza bwa za oocytes binyuze mu kubungabunga ubusugire bwa cytoskeleton.
6. NMN ishobora kugarura ikwirakwira ry'ibitonyanga bya lipide mu mbeba za HFD
Ingano y’ibinure byinshi mu mafunguro (HFD) yari hejuru gato ugereranyije n’iy’ama-oocyte asanzwe mu mafunguro (ND), kandi inyunganizi ya NMN yashoboraga kugabanya ubukana bw’ibitonyanga bya lipide.
7. NMN isubiza ibiro by'umubiri mu bana b'imbeba za HFD
Uburemere bw'abana bavutse mu itsinda ry'indyo irimo ibinure byinshi (HFD) bwari hasi cyane ugereranyije n'ubwo mu itsinda risanzwe ry'indyo (ND), kandi kongeramo indyo ya NMN byasubije ibiro by'abana bavutse mu itsinda ry'indyo ya HFD.
Muri ubu bushakashatsi, abashakashatsi bagaragaje binyuze mu bushakashatsi bw'imbeba ko NMN ifite ubushobozi bwo kunoza ubwiza bw'uturemangingo tw'imbeba z'ingore zibyibushye cyane bitewe n'indyo irimo ibinure byinshi, kandi bagaragaje ko NMN ishobora kugarura imikorere ya mitochondrial no kugabanya kwibumbira kwa ROS mu turemangingo tw'imbeba z'ingore zibyibushye cyane. , kwangirika kwa ADN n'uburyo bw'ibanze bwo gukwirakwiza ibitonyanga bya lipide. Kubwibyo, ubu bushakashatsi buzatanga ingamba zishobora gukoreshwa mu kuvura ibibazo byo kubyara biterwa n'umubyibuho ukabije ku bagore.
Imbonerahamwe:
1.Wang L, Chen Y, Wei J, n'abandi. Gutanga nicotinamide mononucleotide byongera ubwiza bwa ovayiti ku mbeba zibyibushye. Cell Prolif. 2022; e13303. doi10. 1111cpr.13303
Igihe cyo kohereza ubutumwa: 28 Nzeri 2022