Mu myaka ya vuba aha, bitewe n’ubwiyongere bw’imibereho mibi n’igitutu cy’abagore mu mibereho yabo, igipimo cy’indwara ya polycystic ovary syndrome (PCOS) cyarushijeho kugaragara. Ubushakashatsi bwo mu mahanga bwagaragaje ko umubare w’abagore barwaye polycystic ovary syndrome (PCOS) ugera kuri 6% -15%, mu gihe mu Bushinwa, umubare w’abagore barwaye uri hagati ya 6% -10%.
Indwara ya Polycystic ovary syndrome ni indwara ikunze kugaragara ku bagore bari mu kigero cyo kubyara bitewe n’indwara z’imisemburo. Igaragara cyane cyane mu mikorere idasanzwe ya glucose na lipid metabolism ndetse no mu mikorere idakora neza y’imyororokere. Ibipimo ngenderwaho mu gusuzuma indwara ni indwara y’urwego rw’imisemburo (androgen nyinshi), indwara zigabanya ovulation hamwe n’impinduka za polycystic ovarian, kandi abagore benshi bafite PC COS bafite imiterere mibi ya metabolic, nko kudakora insuline, umubyibuho ukabije, na steatosis y’umwijima.
Muri iki gihe, hari imiti mike yo kuvura PCOS. Uburyo busanzwe ni ukunoza PCOS hifashishijwe imiti igabanya androgens no kuziba ikoreshwa ryayo. Ariko kandi, hari ibimenyetso bigaragaza ko imiti igabanya androgens ifite uburozi bukomeye mu mwijima, bityo ikoreshwa ryayo rikaba rike. Kubwibyo, ni ngombwa cyane gushaka ikintu karemano kidafite ingaruka mbi kugira ngo gisimbuze imiti iriho ubu.
Ubushakashatsi buherutse gukorwa na Kaminuza ya New South Wales muri Ositaraliya bwagaragaje ko indwara y’intanga ngabo ya polycystic ifitanye isano no kubura NAD+, kandi ibyavuye mu bushakashatsi byasohotse mu kinyamakuru cya siyansi cyitwa “Molecular Metabolism”.
Itsinda ry’ubushakashatsi ryabanje gutera dihydrotestosterone (DHT) mu mbeba z’ingore mbere na nyuma y’ubugimbi kugira ngo hamenyekane icyitegererezo cy’imbeba ya PC COS, hanyuma nyuma y’ibyumweru 8 by’ubuvuzi bwa NMN, insuline yihuta no gupima ubudahangarwa bwa insuline ya HOMA, ikizamini cyo kwihanganira isukari, ibinure Nyuma y’ibizamini nka histomorphometry, ibisubizo by’imibare bigaragaza:
1. N MN igarura urugero rwa NAD + mu mitsi y'imbeba za P COS
basanze urugero rwa NAD+ mu mitsi y'imbeba za PCOS rwaragabanutse cyane, kandi urugero rwa NAD mu mitsi y'imbeba za PCOS rwarasubiwemo no kugaburira NMN.
2. NMN yongera ubudahangarwa bwa insuline n'umubyibuho ukabije mu mbeba za PCOS
Urugero rwa insuline ruterwa na DHT rwikubye kabiri birenga urugero mu mbeba za PCOS zirya, bishobora kuba bigaragaza ubudahangarwa bwa insuline. Mu kugaburira NMN, byagaragaye ko urugero rwa insuline zirya rwasubijwe ku rugero rwegereye urw'imbeba zisanzwe. Byongeye kandi, uburemere bw'umubiri w'imbeba za PCOS bwiyongereyeho 20%, kandi ibinure byiyongera cyane.
3. NMN igarura ibinure bidasanzwe mu mwijima w'imbeba za PCOS
Kimwe mu biranga indwara ya polycystic ovary syndrome ni ukwishyira kw'ibinure mu mwijima no kwinjizwa kw'umwijima w'ibinure. Nyuma yo gufata NMN, ukwishyira kw'ibinure mu mwijima kudasanzwe mu mbeba za PCOS kwari hafi gucika, maze triglycerides mu mwijima isubira ku rwego rw'imbeba zisanzwe.
Umwanzuro, urugero rwa NAD+ mu mitsi ya PCOS rwagabanutse cyane, kandi PCOS yagabanutse binyuze mu kongeramo NMN, ibanziriza NAD+, ishobora kuba ingamba zishobora gukoreshwa mu kuvura PCOS.
ingero:
[1]. Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Kugabanuka kw'imitsi NAD+ mu buryo bwa hyperandrogenism PCOS imbeba: Uruhare rushoboka mu kugabanuka kwa metabolic. Mol Metab. 9 Nzeri 2022;65:101583. doi: 10.1016/j.molmet.2022.101583. Epub mbere yo gucapa. PMID: 36096453.
Igihe cyo kohereza: Ugushyingo-17-2022