Imiterere ya molekulari: Ingaruka zo kuvura inyongera ya NMN kuri syndrome ya polycystic ovary

Mu myaka yashize, hamwe no kwiyongera kwimibereho itari myiza hamwe n’umuvuduko w’imibereho y’abagore, umubare w’indwara ya syndrome ya polycystic ovary (PCOS) wagaragaye cyane.Ubushakashatsi bw’amahanga bwerekanye ko indwara ya syndrome ya polycystic ovary (PCOS) ku bagore bafite imyaka yo kubyara iri hejuru ya 6% -15%, mu gihe mu Bushinwa, umubare uri hejuru ya 6% -10%.

Indwara ya polycystic ovary ni indwara ikunze kugaragara ku bagore bafite imyaka yo kubyara kubera indwara ya endocrine.Igaragarira cyane cyane muri glucose idasanzwe na metabolisme ya lipide no kudakora neza kwimyororokere.Ibipimo byo kwisuzumisha kwa clinique ni indwara yo mu rwego rwa hormone (androgene yo hejuru), kugabanya indwara ya Ovulation hamwe n’impinduka ya polycystic ovarian, kandi abagore benshi bafite PC COS bafite imiterere mibi ya metabolike, nko kurwanya insuline, umubyibuho ukabije, hamwe na steatose.

Kugeza ubu, hari imiti mike yo kuvura PCOS.Uburyo busanzwe nugutezimbere PCOS muguhitamo no kubuza androgene kurenza imiti igabanya ubukana.Icyakora, hari n'ibimenyetso byerekana ko imiti irwanya andorogene ifite uburozi bukomeye bwumwijima, bityo ikoreshwa ryayo rikaba rito.Kubwibyo, ni ngombwa cyane gushakisha ibintu bisanzwe bidafite ingaruka zo gusimbuza imiti iriho.

ubushakashatsi buherutse gukorwa na kaminuza ya New South Wales muri Ositaraliya bwerekanye ko syndrome ya polycystic ovary ifitanye isano no kubura NAD +, kandi ibyavuye mu bushakashatsi byatangajwe mu kinyamakuru cy'ubumenyi “Molecular Metabolism”.

Itsinda ry’ubushakashatsi ryabanje gutera dihydrotestosterone (DHT) mu buryo bwimbitse mu mbeba z’abagore mbere na nyuma y’ubwangavu kugira ngo zishyireho imbeba y’imbeba ya PC COS, hanyuma nyuma y’ibyumweru 8 bivura NMN, kwiyiriza ubusa insuline hamwe no kurwanya insuline ya HOMA, ikizamini cyo kwihanganira glucose, ibinure Nyuma yo kwipimisha nkibi nka histomorphometrie, ibisubizo byibarurishamibare byerekana:

1. N MN igarura N AD + urwego mumitsi yimbeba P COS
wasanze urwego rwa NAD + mumitsi yimbeba za PCOS rwaragabanutse cyane, kandi urwego rwa NAD mumitsi yimbeba za PCOS rwagaruwe no kugaburira NMN.

2. NMN itezimbere insuline n'umubyibuho ukabije mu mbeba za PCOS
DHT iterwa na insuline urwego rwikubye inshuro ebyiri kwiyiriza imbeba za PCOS, birashoboka ko byerekana insuline.Mu kugaburira NMN, byagaragaye ko urwego rwa insuline rwisonzesha rwasubijwe kurwego rwegereye urwego rwimbeba zisanzwe.Byongeye kandi, uburemere bwumubiri wimbeba za PCOS bwiyongereyeho 20%, kandi ibinure byiyongereye cyane.

3. NMN igarura lipide idasanzwe ya lipide mu mbeba za PCOS
Kimwe mu biranga syndrome ya polycystic ovary ni kwibiza lipide mu mwijima no kwinjiza umwijima w'amavuta.Nyuma yo gufata NMN, umwijima udasanzwe wa lipide wumwijima mu mbeba za PCOS wasaga nkuwakuweho, kandi triglyceride mu mwijima yagarutse kurwego rwimbeba zisanzwe.

umwanzuro, urwego rwa NAD + mumitsi ya PCOS rwaragabanutse cyane, kandi imiterere ya PCOS yagabanutse hongerwaho NMN, ibanziriza NAD +, ishobora kuba ingamba zo kuvura PCOS.

Reba:
[1].Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.Kugabanuka kw'imitsi NAD + muri hyperandrogenism PCOS yimbeba ya PCOS: Uruhare rushoboka muguhindura metabolike.Mol Metab.2022 Nzeri 9; 65: 101583.doi: 10.1016 / j.molmet.2022.101583.Epub mbere yo gucapa.PMID: 36096453.