Uko tugenda dusaza, amagufwa yacu arushaho kuba make kandi ashobora kuvunika, kandi uburyo bwo kuvura ubu bushobora kongera ubucucike bw'amagufwa mu buryo buciriritse. Iki kibazo gikunze kubaho kubera ko impamvu nyamukuru itera osteoporosis (kugabanuka kw'uburemere bw'amagufwa n'ubucucike) itazwi.
Abashakashatsi bo muri Ositaraliya baherutse gusohora ibyavuye mu bushakashatsi bwa siyansi mu kinyamakuru Journal of Gerontology: Series A: NMN ishobora kugabanya gusaza kw'uturemangingo tw'amagufwa y'abantu no guteza imbere gukira kw'amagufwa mu mbeba zirwaye indwara y'amagufwa. Abanditsi bagize bati: "Ibyavuye mu bushakashatsi bigaragaza ko NMN ari umuti mwiza kandi ushoboka wo gukumira indwara y'amagufwa no kongera gukira kw'amagufwa mu bantu bakuze bafite indwara y'amagufwa."
一、NMNbitera imbaraga zo kuvugurura osteoblasts kandi byongera ingano y'amagufwa
Kimwe n'izindi ngingo z'umubiri w'umuntu, amagufwa agizwe n'uturemangingo tuzima. Kubwibyo, amagufwa ashaje kandi yangiritse ahora asimburwa n'amashya. Ariko, uko tugenda dusaza, niko haboneka uturemangingo duke, bitewe nuko uturemangingo dusanzwe tuba uturemangingo tw’ubukure. Uturemangingo tw’ubukure, dushobora kuba dutuma habaho gusaza, ntidushobora gukora amagufwa mashya, bigatera indwara ya osteoporosis.
Abashakashatsi bo muri Ositaraliya bigaga ingaruka za NMN ku ndwara ya osteoporosis bakoresheje ubushakashatsi ku mikurire y’uturemangingo tw’umubiri w’umuntu. Kugira ngo batere abantu gusaza, abashakashatsi bagaragaje ko uturemangingo tw’umubiri tw’umuntu duterwa n’ikintu gitera ububabare cyitwa TNF-⍺. Nubwo TNF-⍺ yihutisha gusaza, kuvura hakoreshejwe NMN byagabanyije gusaza inshuro hafi eshatu, kandi ibisubizo byagaragaje ko NMN yagabanyije imikurire y’uturemangingo tw’umubiri tw’umuntu.
Osteoblast nziza zirema ingingo nshya z'amagufwa zihinduka uturemangingo tw'amagufwa dukuze. Abashakashatsi basanze gutera gusaza hamwe na TNF-⍺ bigabanya ubwinshi bw'uturemangingo tw'amagufwa dukuze. Ariko, NMN yongereye ubwinshi bw'uturemangingo tw'amagufwa dukuze, kandi ibisubizo bigaragaza ko NMN ishobora gutuma amagufwa avuka.
Nyuma y'uko ibyavuye mu bushakashatsi byemeza koNMNAbashakashatsi bagerageje niba ibi bishobora kugabanya osteoblast zishaje kandi bigatuma zihinduka uturemangingo tw’amagufwa dukuze, ibi bikaba byarakozwe n’abahanga mu bushakashatsi. Kugira ngo babigereho, bakuyemo intanga ngabo z’imbeba z’ingore maze bavunagura imyakura yazo, bigatuma amagufwa atakaza uburemere buranga osteoporosis.
Kugira ngo bapime ingaruka za NMN ku ndwara ya osteoporosis, abashakashatsi bateye imbeba za osteoporosis 400 mg/kg/ku munsi ya NMN mu gihe cy'amezi 2. Byagaragaye ko imbeba zarwaye osteoporosis zari ziyongereyeho uburemere bw'amagufwa, bigaragaza ko NMN yahinduye gato ibimenyetso bya osteoporosis. Ukoresheje amakuru ajyanye n'amagufwa y'abantu, ibi bivuze ko NMN ishobora kuvura osteoporosis binyuze mu kongera imiterere y'amagufwa.
Effects Ingaruka zongera amagufwa ya NMN
Ibisubizo by'ubushakashatsi bigaragaza koNMNishobora guteza imbere ishingwa ry'amagufwa. Bigaragara ko ibikora mu buryo butandukanye, harimo no kuvugurura uturemangingo tw'amagufwa, ari ingenzi mu ishingwa ry'amagufwa na NAD+, ari ingenzi mu ishingwa ry'amagufwa. Uturemangingo tw'amagufwa dutandukanye mu turemangingo tw'amagufwa, kandi abashakashatsi bagaragaje ko NMN ishobora no kuvugurura osteoblasts.
Ibi byavumbuwe bigaragaza ko NMN ishobora kongera imiterere y'amagufwa binyuze mu guteza imbere ubuzima bw'uturemangingo twinshi tw'amagufwa mu nzira yo gushinga amagufwa. Nubwo nta bushakashatsi bwagaragaje ko NMN ishobora guteza imbere imiterere y'amagufwa ku bantu bafite indwara ya osteoporosis, birashoboka ko NMN ishobora gukumira iterambere ry'amagufwa rigenda rikura uko abantu basaza.
Igihe cyo kohereza: Mutarama 18-2024