Hypopigmentation n'indwara y'uruhu, igaragazwa cyane no kugabanuka kwa melanin.Ibimenyetso bikunze kugaragara harimo vitiligo, albinism na hypopigmentation nyuma yo gutwika uruhu.Kugeza ubu, uburyo nyamukuru bwo kuvura hypopigmentation ni ubuvuzi bwo mu kanwa, ariko imiti yo mu kanwa izatera atrophyi y’uruhu, kutagira gastrointestinal nizindi ngaruka mbi.Kubwibyo, birakenewe guteza imbere ibintu bisanzwe bidafite ingaruka zo kuvura hypopigmentation.
Vuba aha, Raporo y’ubumenyi yasohoye inyandiko yiswe "Ubushakashatsi buri kuri gahunda bugaragaza ubushobozi bwa spermidine yo kuvura hypopigmentation | binyuze mu guhagarika poroteyine ziterwa na melanogenezi".Ibisubizo byerekana ko spermidine ishobora kuvurwa no guhagarika poroteyine ziterwa na melanogenezi.hypopigmentation.
Treatment Kuvura spermidine byongera umusaruro wa melanin
Mu rwego rwo kwiga ku ngaruka za spermidine ku musaruro wa melanin, itsinda ry’ubushakashatsi ryavuye melanine mu ngirabuzimafatizo za MNT-1 hamwe na spermidine itandukanye.Binyuze mu isesengura ryinshi, byagaragaye ko kuvura spermidine byongera umusaruro wa melanin.
二 erm Spermidine irashobora kugenga sisitemu yo kwangirika kwa poroteyine ijyanye na melanogenez
Mu rwego rwo kwerekana ko intanga ngabo zishobora kugenga ingirabuzimafatizo zigira uruhare mu iyangirika rya poroteyine, itsinda ry’ubushakashatsi ryasanze ingirabuzima fatizo 181 zagabanijwe na gen 82 zigengwa na sisitemu yo kuvura ingirabuzimafatizo zavuwe, usibye gen zijyanye na melanogenez.Kugira ngo turusheho kubigaragaza, itsinda ry’ubushakashatsi ryasesenguye ingaruka za spermidine ku rwego rwo kwerekana imiterere y’umuryango wa tyrosinase TYR, TRP-1 na TRP-2, zikaba ari gen zigenzura cyane umusaruro wa melanine.Urwego rwa mRNA rwerekana ko spermidine idahinduye imvugo ya melanogenezi.Nyamara, ibikorwa bya genes nyinshi bihindurwa na spermidine kandi bifitanye isano no kwangirika kwa poroteyine.Ingirabuzimafatizo nyinshi zahinduwe zijyanye na hose, ni sisitemu yo kwangiza poroteyine ijyanye na melanogenez.
三 pSpermidine igenga itungamubiri rya poroteyine kandi iteza imbere umusaruro wa melanin.
Umusaruro wa melanine ugengwa nuburinganire bwa synthesis hamwe no kwangirika kwa poroteyine zijyanye na melanin.Spermidine ivura ingirabuzimafatizo za TYR, TRP-1 na TRP-2.Binyuze mu bikorwa bya genes zitwara abantu SLC3A2, SLC7A1, SLC18B1 na SLC22A18, irashobora kongera urwego rwa polyamine mu ngirabuzimafatizo, bityo bikongerera umutekano wa poroteyine zijyanye n’umusemburo wa melanin kugira ngo uteze imbere umusaruro wa melanine muri vivo.
Mu gusoza, ubu bushakashatsi bwerekana ko spermidine isanzwe ivanze ifite uruhare runini mukuvura hypopigmentation, kandi ifite agaciro gakoreshwa mubijyanye no kwisiga nibicuruzwa byubuzima mugihe kizaza.
Reba:
[1] .Brito, S., Heo, H., Cha, B. n'abandi.Ubushakashatsi butunganijwe bugaragaza ubushobozi bwa spermidine yo kuvura hypopigmentation binyuze mu guhagarika poroteyine ziterwa na melanogenezi.Sci Rep 12, 14478 (2022).https://doi.org/10.1038/s41598-022-18629-3.
Igihe cyo kohereza: Nzeri-28-2022