Hypopigmentation ni indwara y'uruhu, igaragazwa cyane cyane no kugabanuka kwa melanin. Ibimenyetso bikunze kugaragara birimo vitiligo, albinism na hypopigmentation nyuma yo kubyimba k'uruhu. Kuri ubu, uburyo bw'ingenzi bwo kuvura hypopigmentation ni imiti yo kunywa, ariko imiti yo kunywa itera uruhu gucika intege, kubabara mu gifu n'izindi ngaruka mbi. Kubwibyo, ni ngombwa gukora ikintu karemano kidafite ingaruka mbi kugira ngo kivure hypopigmentation.
Vuba aha, Scientific Reports yasohoye inkuru ifite umutwe ugira uti "Ubushakashatsi bwakozwe ku buryo bunonosoye bwerekana ubushobozi bwa spermidine mu kuvura indwara ya hypopigmentation | binyuze mu gutuma poroteyine zifitanye isano na melanogeneis zihagarara". Ibisubizo bigaragaza ko spermidine ishobora kuvurwa binyuze mu gutuma poroteyine zifitanye isano na melanogeneis zihagarara.
Kuvura Spermidine byongera umusaruro wa melanin
Kugira ngo hamenyekane ingaruka z'intanga ngabo ku ikorwa rya melanin, itsinda ry'ubushakashatsi ryavuje melanin mu turemangingo twa MNT-1 hakoreshejwe ingano zitandukanye z'intanga ngabo. Binyuze mu isesengura ry'imibare, byagaragaye ko kuvura impuza ngabo byongera ikorwa rya melanin.
Spermidine ishobora kugenzura uburyo poroteyine yangirika bitewe n'uko melanogeneis
Kugira ngo hagaragazwe ko spermidine ishobora kugenzura imiterere y’uturemangingo tugira uruhare mu kwangirika kwa poroteyine, itsinda ry’ubushakashatsi ryasanze gene 181 zagabanutseho imiterere yazo naho gene 82 zagabanutseho imiterere yazo binyuze mu gushakisha uturemangingo twavuwe n’intanga ngabo, hatabariwemo gene zijyanye na melanogenezi. Kugira ngo bakomeze kwemeza, itsinda ry’ubushakashatsi ryasesenguye ingaruka z’intanga ngabo ku rwego rw’imikorere y’uturemangingo twa tyrosinase TYR, TRP-1 na TRP-2, ari zo gene zigenzura cyane ikorwa rya melanin. Urwego rw’imikorere ya mRNA rwemeje ko spermidine itahinduye imiterere y’uturemangingo dufitanye isano na melanogenezi. Ariko, imikorere y’uturemangingo twinshi ihinduka bitewe n’imikorere y’uturemangingo kandi ifitanye isano no kwangirika kwa poroteyine. gene nyinshi zahindutse zifitanye isano no kuba ahantu hose, ari na yo sisitemu yo kwangirika kwa poroteyine ifitanye isano na melanogenezi.
三．Spermidine igenzura uburyo poroteyine ziguma zihagaze kandi igateza imbere ikorwa rya melanin.
Ikorwa rya melanin rigengwa n'uburyo poroteyine zifitanye isano na melanin zikorwa kandi zikangirika. Spermidine ivura TYR, TRP-1 na TRP-2. Binyuze mu bikorwa bya gene zitwara SLC3A2, SLC7A1, SLC18B1 na SLC22A18, ishobora kongera urugero rwa polyamines mu turemangingo, bityo ikongera uburinganire bwa poroteyine zijyanye no gukora melanin kugira ngo iteze imbere ikorwa rya melanin mu mubiri.
Mu gusoza, ubu bushakashatsi bwerekana ko spermidine isanzwe ifite uruhare runini mu kuvura indwara yo gucika kw'ibara ry'uruhu, kandi ifite akamaro runaka mu bijyanye n'ubwiza n'ibicuruzwa by'ubuzima mu gihe kizaza.
Icyitonderwa:
[1].Brito, S., Heo, H., Cha, B. n'abandi. Ubushakashatsi bwakozwe ku buryo bwimbitse bwerekanye ubushobozi bwa spermidine mu kuvura indwara ya hypopigmentation binyuze mu gutuma poroteyine zifitanye isano na melanogeneis zihagarara. Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Igihe cyo kohereza ubutumwa: 28 Nzeri 2022