Clenbuterol, ni β2-adrenergic agonist (β2-adrenergic agonist), isa na ephedrine (Ephedrine), ikoreshwa kenshi mubuvuzi mu kuvura indwara zidakira zifata ibihaha (COPD), Ikoreshwa kandi nka bronchodilator kugirango igabanye ubukana bukabije bwa asima.Mu ntangiriro ya za 1980, isosiyete y'Abanyamerika Cyanamid yavumbuye ku bw'impanuka ko ifite ingaruka zigaragara zo guteza imbere iterambere, kuzamura inyama zinanutse no kugabanya ibinure, bityo ikoreshwa nka clenbuterol mu bworozi.Icyakora, kubera ingaruka zabyo, Umuryango w’ubumwe bw’ibihugu by’i Burayi wabujije ikoreshwa rya clenbuterol nk'inyongeramusaruro kuva ku ya 1 Mutarama 1988. Byabujijwe na FDA mu 1991. Mu 1997, Minisiteri y’ubuhinzi muri Repubulika y’Ubushinwa yabujije rwose. gukoresha imisemburo ya beta-adrenergique mu kugaburira no gutanga ubworozi, na hydrochloride ya Clenbuterol iri ku mwanya wa mbere.
Nyamara, ubwoko bwa Clenbuterol buherutse kwerekana ko bugabanya ibyago byindwara ya Parkinson.Kugirango hemezwe (cyangwa byombi) isomers itanga iyi ngaruka, Clenbuterol enantiomer isukuye igomba kwigwa ukwayo.
Mu kiganiro giheruka, itsinda ry’ubushakashatsi bwa Elisabeth Egholm Jacobsen wo mu ishami ry’ubutabire, kaminuza y’ubumenyi n’ikoranabuhanga muri Noruveje, ku bufatanye na Dr. Zhu Wei wo muri Shangke Bio, ryagize uruhare mu guhuza ketoreductase KRED na cofactor nicotinamide adenine dinucleoside fosifate (NADPH) ).(R) -1- (4-Amino-3,5-dichlorophenyl) -2-bromoethan-1-ol, ee> 93%;na (S) -N- (2 yashizwemo na sisitemu imwe, 6-Dichloro-4- (1-hydroxyethyl) phenyl) acetamide, ee> 98%.Abahuza bombi bavuzwe haruguru nibishobora kubanziriza isomers ya clenbuterol.Ketoreductase ES-KRED-228 yakoreshejwe muri ubu bushakashatsi yavuye muri Shangke Biopharmaceutical (Shanghai) Co., Ltd. Ku ya 4 Ugushyingo 2018.
Igihe cyo kohereza: Kanama-26-2022