SyncoZymes

amakuru

Ubushakashatsi ku iterambere ry’ikorwa rya enzymes z’ibintu bishobora kuba ibya mbere bya Clenbuterol ku bufatanye hagati ya Kaminuza ya Siyansi n’Ikoranabuhanga yo muri Noruveje na Shangke Biomedical

Clenbuterol, ni agonist ya β2-adrenergic (agonist ya β2-adrenergic), isa na ephedrine (Ephedrine), ikunze gukoreshwa mu buvuzi mu kuvura indwara idakira yo mu bihaha (COPD). Ikoreshwa kandi nk'umuti wo koroshya imitsi kugira ngo igabanye ubukana bw'indwara ya asima. Mu ntangiriro za 1980, ikigo cy'Abanyamerika cyitwa Cyanamid cyavumbuye ku buryo butunguranye ko ifite ingaruka zigaragara zo guteza imbere imikurire, kongera umuvuduko w'inyama zitarimo ibinure no kugabanya ibinure, bityo ikoreshwa nka clenbuterol mu bworozi bw'amatungo. Ariko, kubera ingaruka mbi zayo, Umuryango w'Uburayi wabujije ikoreshwa rya clenbuterol nk'inyongera ku biryo kuva ku ya 1 Mutarama 1988. Yahagaritswe na FDA mu 1991. Mu 1997, Minisiteri y'Ubuhinzi ya Repubulika y'Abaturage y'Ubushinwa yabujije cyane ikoreshwa rya beta-adrenergic hormones mu gutunganya ibiryo n'ubworozi, kandi Clenbuterol hydrochloride yaje ku mwanya wa mbere.

Ariko, Clenbuterol yo mu bwoko bwa racemic iherutse kugaragara ko igabanya ibyago byo kurwara indwara ya Parkinson. Kugira ngo hemezwe isomer (cyangwa zombi) zigira iyi ngaruka, Clenbuterol enantiomer nziza igomba kwigwa ukwayo.

Mu nkuru iherutse gusohoka, itsinda ry’ubushakashatsi rya Elisabeth Egholm Jacobsen wo mu Ishami rya Chimie, Kaminuza ya Siyansi n’Ikoranabuhanga yo muri Noruveje, ku bufatanye na Dr. Zhu Wei wo muri Shangke Bio, ryashishikarije ikorwa rya ketoreductase KRED na cofactor nicotinamide adenine dinucleoside phosphate (NADPH). (R)-1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-ol, ee > 93%; na ​​(S)-N-(2) byakozwe na sisitemu imwe ,6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee > 98%. Ibi byombi byavuzwe haruguru ni ibishobora kuba imbarutso ya isomer za clenbuterol. Ketoreductase ES-KRED-228 yakoreshejwe muri ubu bushakashatsi yaturutse muri Shangke Biopharmaceutical (Shanghai) Co., Ltd. Ibyavuye mu bushakashatsi "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" byasohotse muri "Catalysts" ku ya 4 Ugushyingo 2018.

Iterambere ry'ubushakashatsi ku bijyanye no gukora enzymes

Igihe cyo kohereza: Kanama-26-2022