Indwara yo mu mara iterwa n'imirasire ni ikibazo gikunze kugaragara ku bantu bazima igihe kirekire nyuma yo kuvurwa hakoreshejwe imirasire yo mu nda no mu kibuno. Kuri ubu, nta buryo buhari bwo kuvura indwara yo mu mara iterwa n'imirasire. Ubushakashatsi bwagaragaje ko nicotinamide mononucleotide (NMN) ifite ubushobozi bwo kugenzura ibinyabuzima byo mu mara. Ibimera byo mu mara ni mikorobe isanzwe mu mara y'umuntu, ishobora gukora intungamubiri zitandukanye zikenewe kugira ngo umuntu akure neza. Iyo ibimera byo mu mara bitameze neza, bizatera indwara zitandukanye.
Vuba aha, Ishuri Rikuru ry’Ubuvuzi ry’Ubushinwa na Peking Union Medical College basohoye ibyavuye mu bushakashatsi mu kinyamakuru International Journal of Radiation Biology, byagaragaje ko NMN ishobora kugabanya fibrosis y’amara iterwa n’imirasire binyuze mu kugenzura ibimera byo mu mara.
Mbere na mbere, itsinda ry’ubushakashatsi ryagabanyije imbeba mu matsinda yo kugenzura, itsinda rya NMN, itsinda rya IR n’itsinda rya NMNIR, maze bahaye itsinda rya IR n’itsinda rya NMNIR imirasire ya 15 Gy mu nda. Hagati aho, inyongeramusaruro ya NMN yahawe itsinda rya NMN n’itsinda rya NMNIR ku gipimo cya buri munsi cya 300mg/kg. Nyuma yo kuyifata igihe runaka, binyuze mu kubona umwanda w’imbeba, microflora yo mu mara n’ibimenyetso by’imitsi y’amara, ibisubizo byagereranyijwe byagaragaje ko:
1. NMN ishobora gusana imiterere n'imikorere y'ibimera byo mu mara bihungabanywa n'imirasire.
Mu kugereranya uburyo bwo kubona ibinyabuzima byo mu mara hagati y’itsinda rya IR n’itsinda rya NMNIR, byagaragaye ko imbeba zo mu itsinda rya IR zongereye ubwinshi bw’ibinyabuzima byangiza amara, nka Lactobacillus du, Bacillus faecalis, nibindi. Igitangaje ni uko imbeba zo mu itsinda rya NMNIR zahinduye ubwinshi bw’ibinyabuzima byo mu mara kandi zongera ubwinshi bw’ibinyabuzima by’ingirakamaro mu mara, nka bagiteri za AKK, zuzuza NMN. Ubushakashatsi bwerekana ko NMN ishobora gusana imiterere n’imikorere y’ibinyabuzima byo mu mara bitari mu rugero bitewe n’imirasire.
2. NMN igabanya fibrosis yo mu mara iterwa n'imirasire
Urugero rwa aSMA (Fibrosis Marker) mu mbeba zahuye n’imirasire rwiyongereye cyane. Nyuma yo kongerwamo NMN, si urugero rwa aSMA gusa rwagabanutse cyane, ahubwo n’indwara yo kubyimba TGF-b yateraga fibrosis mu mara yagabanutse cyane, bigaragaza ko kongerwamo NMN bishobora kugabanya fibrosis mu mara iterwa n’imirasire.
(Ishusho ya 1. Ubuvuzi bwa NMN bugabanya fibrosis yo mu mara iterwa n'imirasire)
Kubera ko ibintu by’ikoranabuhanga bikwirakwira cyane, imirasire igira ingaruka zikomeye ku kazi k’abantu no ku buzima bwabo, cyane cyane ku bimera byo mu mara igihe kirekire. NMN ifite ingaruka zikomeye ku buzima bw’amara. Iyi ngaruka ntigerwaho gusa n’ikintu kimwe cyangwa inzira runaka, ahubwo inagenzurwa n’imiterere y’ibimera kugira ngo ikomeze imikorere y’amara mu buryo buhamye mu mpande n’ibyerekezo bitandukanye, ibi kandi bitanga icyerekezo cy’ingenzi ku byiza bitandukanye bya NMN.
Amareferensi:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): NMN igabanya fibrosis yo mu mara iterwa n'imirasire ihindura mikorobe yo mu nda, Ikinyamakuru mpuzamahanga cy’imirasire y’ibinyabuzima, DOI: 10.1080 / 09553002.2023.2145029
Igihe cyo kohereza: Ukuboza-08-2022