NMN igabanya imishwarara iterwa na fibrosis yo mu mara ihindura mikorobe yo mu nda

Fibrosis yo mu mara iterwa n'imirasire ni ingorane zisanzwe z'abacitse ku icumu nyuma yo kuvura inda na pelvic radiotherapi.Kugeza ubu, nta buryo buhari bwo kuvura bwo kuvura fibrosis yo mu mara iterwa n'imirasire.Ubushakashatsi bwerekanye ko nicotinamide mononucleotide (NMN) ifite ubushobozi bwo kugenga ibimera byo munda.Ibimera byo munda ni mikorobe isanzwe mu mara yumuntu, ishobora guhuza intungamubiri zitandukanye zikenewe kugirango umuntu akure kandi akure.Ibimera byo munda bimaze kutaringaniza, bizatera indwara zitandukanye.
Vuba aha, Ishuri Rikuru ry’Ubuvuzi ry’Ubushinwa na Peking Union Medical College ryasohoye ibyavuye mu bushakashatsi mu kinyamakuru International Journal of Radiation Biology, ryerekanye ko NMN ishobora kugabanya fiboside yo mu mara iterwa n’imirasire igenga ibimera byo mu nda.
Ubwa mbere, itsinda ry’ubushakashatsi ryagabanyije imbeba mu itsinda rishinzwe kugenzura, itsinda rya NMN, itsinda rya IR n’itsinda rya NMNIR, maze ritanga imirasire y’inda 15 ya Gy itsinda rya IR nitsinda rya NMNIR.Hagati aho, inyongera ya NMN yahawe itsinda rya NMN nitsinda rya NMNIR ku munsi wa 300mg / kg.Nyuma yo kuyifata mugihe runaka, mugushakisha umwanda wimbeba, microflora yo munda hamwe nibimenyetso bya tissue colon, ibisubizo byagereranije byerekanye ko:

1. NMN irashobora gusana imiterere n'imikorere ya flora yo munda ihungabanywa nimirase.
Mugereranije no kumenya ibimera byo munda hagati yitsinda rya IR nitsinda rya NMNIR, byagaragaye ko imbeba zo mu itsinda rya IR zongereye ubwinshi bw’ibimera byo mu mara byangiza, nka Lactobacillus du, Bacillus faecalis, nibindi. Igitangaje ni uko imbeba zo mu itsinda rya NMNIR zahinduye ubudasa bw’ibimera byo mu nda. kandi yongereye ubwinshi bwibimera byo munda byingirakamaro, nka bagiteri AKK, hiyongeraho NMN.Ubushakashatsi bwerekana ko NMN ishobora gusana imiterere n'imikorere ya flora yo munda idahwitse kubera imirasire.

2. NMN igabanya fibrosis yo munda iterwa nimirasire
Urwego rwa ASMA (Fibrosis Marker) mu mbeba zanduye imirasire yiyongereye cyane.Nyuma yo kongererwa kwa NMN, ntabwo urwego rwa marike ya ASMA rwaragabanutse cyane, ariko nanone ibintu bitera TGF-b byateje fibrosis yo munda byagabanutse cyane, byerekana ko inyongera ya NMN ishobora kugabanya fiboside yo munda iterwa nimirasire.

(Igicapo 1. Kuvura NMN bigabanya fibrosis yo munda iterwa nimirasire)

Mugihe cyubwinshi bwibicuruzwa bya elegitoroniki, imirasire igira ingaruka kumurimo wabantu no mubuzima bwabo, cyane cyane ku bimera byo munda igihe kirekire.NMN igira ingaruka zikomeye zo kurinda ubuzima bw'amara.Ingaruka ntizigaragazwa gusa ningingo imwe cyangwa inzira runaka, ariko kandi no kugenzura imiterere yikwirakwizwa ryibimera kugirango iteze imbere imikorere yimara iturutse kumpande zitandukanye, nayo itanga ibisobanuro byingenzi kubyiza bitandukanye bya NMN.

Reba:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): NMN igabanya fibrosis yo mu mara iterwa n'imirasire ihindura mikorobe yo mu nda, Ikinyamakuru mpuzamahanga cy’imirasire y’ibinyabuzima, DOI: 10.1080 / 09553002.2023.2145029