Triglyceride (TG) ni ubwoko bw'ibinure bifite ingano nini mu mubiri w'umuntu. Ingingo zose n'ingingo z'umubiri w'umuntu zishobora gukoresha triglyceride kugira ngo zitange ingufu, kandi umwijima ushobora gukora triglyceride no kuyibika mu mwijima. Iyo triglyceride yiyongereye, bivuze ko umwijima wiyongeramo ibinure byinshi, ari byo umwijima ufite ibinure byinshi. Triglyceride ni ubwoko bwa hyperlipidemia, kandi ingaruka zayo nyamukuru ku mubiri w'umuntu ni ugutera atherosclerosis, kuziba imiyoboro y'amaraso no kugabanuka kw'amaraso mu mubiri. Byongeye kandi, ubushakashatsi bwagaragaje ko triglyceride nyinshi zishobora no gutera umuvuduko ukabije w'amaraso, udukoko tw'indurwe, pancreatitis, indwara ya Alzheimer n'ibindi.
Ubushakashatsi buherutse gukorwa mu Buyapani ku bantu bwongeye kugaragaza akamaro ka NMN ku mubiri w'umuntu. Binyuze mu igeragezwa ry'ubuvuzi ku bantu, itsinda ry'ubushakashatsi ryagaragaje ko gutera NMN mu mitsi ari byiza ku mubiri w'umuntu, ibyo bikaba bidatuma gusa ingano ya NAD+ mu maraso igabanuka cyane, ahubwo binagabanya cyane urugero rwa triglyceride mu maraso hatabayeho kwangiza uturemangingo tw'amaraso.
Itsinda ry’ubushakashatsi ryatoranyije abakorerabushake 10 bazima (abagabo 5 n’abagore 5, bafite hagati y’imyaka 20 na 70). Nyuma yo kwiyiriza ubusa amasaha 12, 300mg ya NMN yashongeshejwe muri 100ml ya saline hanyuma iterwa mu bakorerabushake binyuze mu mitsi yo mu kuboko (5mL/umunota). Imirasire yo mu gituza yafashwe mbere na nyuma yo guterwa NMN, maze hapimwa uburemere, ubushyuhe, umuvuduko w’amaraso, umutima n’umwuka wa ogisijeni mu maraso. Amaraso n’inkari byakusanyijwe kugira ngo bipimwe. Binyuze mu isesengura rigereranya ibisubizo byinshi by’ibizamini, byagaragaye ko ibimenyetso by’ingenzi by’umwijima, pancreas, umutima n’impyiko nta mpinduka zigaragara bifite, kandi byongeyeho, ntibizagira ingaruka ku bimenyetso by’ingenzi by’uturemangingo dutukura, uturemangingo tw’amaraso twera na plaquettes mu maraso, kandi abitabiriye nta ngaruka mbi bafite.
Ni ngombwa kumenya ko urugero rwa triglyceride mu maraso rwahindutse ku buryo bugaragara. Nyuma y’uko abakoreweho ubushakashatsi batewe inshinge za NMN mu gihe cy’igice cy’isaha, urugero rwa triglyceride rwagabanutse ku buryo bugaragara, kugeza nyuma y’amasaha 5, nubwo hari icyerekezo gito cyo gukira, iri tandukaniro rikomeye ryarakomeje.
Kuva ku bushakashatsi bwakozwe mbere yo kuvura inyamaswa kugeza ku bushakashatsi bwakozwe ku bantu, akamaro ka NMN ku mubiri w'umuntu karagenzuwe neza. Ubu bushakashatsi bwakozwe ku bantu bugaragaza akamaro ka NMN mu kugabanya triglyceride, ikaba ari inkuru nziza ku bantu bafite umubyibuho ukabije n'abageze mu zabukuru.
Amareferensi:
[1]. Kimura S, Ichikawa M, Sugawara S, n'abandi (05 Nzeri 2022) Nicotinamide Mononucleotide irahinduka mu buryo bwizewe kandi igabanya cyane urugero rwa Triglyceride mu maraso ku bantu bazima. Cureus 14(9): e28812. doi:10.7759/cureus.28812
Igihe cyo kohereza: Ugushyingo-11-2022