Ubuvuzi bwa Clinical kumubiri wumuntu: NMN irashobora kugabanya neza urugero rwa triglyceride

Triglyceride (TG) ni ubwoko bwibinure bifite ibintu byinshi mumubiri wumuntu.Ibice byose hamwe nuduce twumubiri wumuntu birashobora gukoresha triglyceride kugirango bitange ingufu, kandi umwijima urashobora guhuza triglyceride ukabika mu mwijima.Niba triglyceride yiyongereye, bivuze ko umwijima urundanya amavuta menshi, akaba ari umwijima w'amavuta.Triglyceride ni ubwoko bwa hyperlipidemiya, kandi ingaruka mbi zayo ku mubiri w'umuntu ni ugutera aterosklerose, guhagarika imiyoboro y'amaraso hamwe na trombose.Byongeye kandi, ubushakashatsi bwerekanye ko triglyceride nyinshi ishobora no gutera hypertension, gallstone, pancreatitis, indwara ya Alzheimer nibindi.

Ubushakashatsi bujyanye n’ubuvuzi bwa muntu mu Buyapani bwongeye kwerekana inyungu za NMN ku mubiri w’umuntu.Binyuze mu bigeragezo by’amavuriro by’abantu, itsinda ry’ubushakashatsi ryerekanye ko gutera inshinge za NMN bifite umutekano ku mubiri w’umuntu, ibyo bikaba bidashobora kongera gusa urugero rw’amaraso NAD +, ariko kandi bikagabanya cyane urugero rwa triglyceride mu maraso bitangiza selile.

Itsinda ry’ubushakashatsi ryashakishije abakorerabushake 10 bafite ubuzima bwiza (abagabo 5 n’abagore 5, bafite imyaka 20 ~ 70).Nyuma yo kwiyiriza amasaha 12, 300mg ya NMN yashongeshejwe muri saline 100mL hanyuma yinjizwa mubukorerabushake binyuze mumitsi (5mL / min).Isanduku ya X-ray yafashwe mbere na nyuma yo guterwa NMN, hanyuma hapimwa uburemere, ubushyuhe, umuvuduko wamaraso, impiswi nuzuye byuzuye ogisijeni.Amaraso n'inkari byakusanyirijwe hamwe kugirango bipimishe.Binyuze mu isesengura rigereranya ryibisubizo byinshi byipimishije, usanga ibimenyetso nyamukuru byumwijima, pancreas, umutima nimpyiko bidahinduka bigaragara, kandi byongeye, ntabwo bizagira ingaruka kubimenyetso nyamukuru bigize selile zitukura, selile yera na platine mu maraso, kandi abayitabiriye nta reaction mbi bafite.

Birakwiye ko tumenya ko urugero rwa triglyceride mumaraso rwahindutse bigaragara.Nyuma yuko amasomo yakiriye inshinge ya NMN mugihe cyigice cyisaha, urwego rwa triglyceride rwaragabanutse kuburyo bugaragara, kugeza nyuma yamasaha 5, nubwo habaye inzira yo gukira gato, iri tandukaniro rikomeye riracyariho.

Kuva mubushakashatsi bwinyamanswa kugeza kubushakashatsi bwubuvuzi bwabantu, ibyiza bya NMN kumubiri wumuntu byagenzuwe neza.Ubu bushakashatsi bwubuvuzi bwabantu bugaragaza imikorere ya NMN mukugabanya triglyceride, ninkuru nziza kubantu bafite umubyibuho ukabije.

Reba:
[1].Kimura S, Ichikawa M, Sugawara S, n'abandi..Kureus 14 (9): e28812.doi: 10.7759 / gukiza.28812